Download e-book for kindle: Adoptive immunotherapy : methods and protocols by Burkhard Ludewig, Matthias W. Hoffmann

By Burkhard Ludewig, Matthias W. Hoffmann

ISBN-10: 1588294064

ISBN-13: 9781588294067

ISBN-10: 1592598625

ISBN-13: 9781592598625

An authoritative number of optimum strategies for generating and characterizing the immunologically lively cells and effector molecules now gaining vast use within the medical remedy of sufferers. benefiting from the most recent applied sciences, the authors current quite simply reproducible experimental protocols for the examine of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and scientific purposes and at the growth of chosen ways in medical trials. extra chapters hide the molecular definition of goal antigens, mathematical modeling techniques to immunotherapy, and the usage of regulatory T cells. The protocols give the opportunity to check the adoptive move of adapted antigen-specific immune cells and to enhance the medical program of adoptive immunotherapy.

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Extra resources for Adoptive immunotherapy : methods and protocols

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A. and Gilboa, E. (2002) Emerging clinical applications of RNA. Nature 418, 252–258. 110. , and Steinkasserer, A. (2001) Viral vectors for dendritic cell-based immunotherapy. Trends Immunol. 22, 102–107. 111. 111 Dietz, A. , and Vuk-Pavlovic, S. (1998) High efficiency adenovirus-mediated gene transfer to human dendritic cells. Blood 91, 392–398. 112. , et al. (1999) Identification of five MAGE-A1 epitopes recognized by cytolytic T lymphocytes obtained by in vitro stimulation with dendritic cells transduced with MAGE-A1.

Immunol. 164, 3095–3101. 19. 19 Wherry, E. , Becker, T. , et al. (2003) Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 4, 225–234. 20. 20 van Stipdonk, M. , Lemmens, E. , and Schoenberger, S. P. (2001) Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2, 423–429. 21. , and Matthews, J. N. S. (2002) Statistical Methods in Medical Research. Blackwell Science, Oxford, UK. 22. Baker, C.

Mathematical Approach to DC Immunotherapy 19 2 A Mathematical Approach for Optimizing Dendritic Cell-Based Immunotherapy Gennady Bocharov, Neville J. Ford, and Burkhard Ludewig Summary Adoptive dendritic cell (DC)-based immunotherapy represents a promising approach to overcome peripheral tolerance against autologous tumor antigens and to maintain protective antitumor immunity. The translation of successful preclinical studies, however, appears to be hampered by new complexities associated with the clinical situation.

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Adoptive immunotherapy : methods and protocols by Burkhard Ludewig, Matthias W. Hoffmann


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