By Burkhard Ludewig, Matthias W. Hoffmann
An authoritative number of optimum strategies for generating and characterizing the immunologically lively cells and effector molecules now gaining vast use within the medical remedy of sufferers. benefiting from the most recent applied sciences, the authors current quite simply reproducible experimental protocols for the examine of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and scientific purposes and at the growth of chosen ways in medical trials. extra chapters hide the molecular definition of goal antigens, mathematical modeling techniques to immunotherapy, and the usage of regulatory T cells. The protocols give the opportunity to check the adoptive move of adapted antigen-specific immune cells and to enhance the medical program of adoptive immunotherapy.
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Extra resources for Adoptive immunotherapy : methods and protocols
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Mathematical Approach to DC Immunotherapy 19 2 A Mathematical Approach for Optimizing Dendritic Cell-Based Immunotherapy Gennady Bocharov, Neville J. Ford, and Burkhard Ludewig Summary Adoptive dendritic cell (DC)-based immunotherapy represents a promising approach to overcome peripheral tolerance against autologous tumor antigens and to maintain protective antitumor immunity. The translation of successful preclinical studies, however, appears to be hampered by new complexities associated with the clinical situation.
Adoptive immunotherapy : methods and protocols by Burkhard Ludewig, Matthias W. Hoffmann