George F. Vande Woude; George Klein (Eds.)'s Advances in Cancer Research PDF

By George F. Vande Woude; George Klein (Eds.)

ISBN-10: 0123747724

ISBN-13: 9780123747723

Advances in melanoma study offers necessary info at the fascinating and fast-moving box of melanoma research. In this half A volume, outstanding and unique studies supply an summary and synthesis of the most recent recommendations and findings when it comes to Clusterin. Chapters contain the shifiting stability among CLU types in the course of tumor development, uclear CLU and the destiny of the cellphone, and Oxidative rigidity in malignant development.

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Sci. USA 86, 7123–7127. Jordan-Starck, T. , et al. (1994). Mouse apolipoprotein J: Characterization of a gene implicated in atherosclerosis. J. Lipid Res. 35, 194–210. , et al. (1989). Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: A link between the complement and reproductive systems. Embo J. 8, 711–718. , et al. (1992). SP-40,40, a protein involved in the control of the complement pathway, possesses a unique array of disulphide bridges. FEBS Lett.

At this purpose, in vitro experiments using epithelial neoplastic (MCF-7, Caco-2, HepG2) cells and nonneoplastic cell lines (MCF-12F) confirmed a nuclear localization of CPT1 protein exclusively in neoplastic cells. Moreover, histone deacetylase (HDAC) activity showed significantly higher levels in nuclear extracts from neoplastic than from control cells. HDAC1 and CPT1 proteins were coimmunoprecipitated in nuclear extracts from MCF-7 cells. The treatment with HDAC inhibitors such as trichostatin A and butyrate significantly decreased nuclear expression of CPT1 and its binding to HDAC1.

Mouse apolipoprotein J: Characterization of a gene implicated in atherosclerosis. J. Lipid Res. 35, 194–210. , et al. (1989). Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: A link between the complement and reproductive systems. Embo J. 8, 711–718. , et al. (1992). SP-40,40, a protein involved in the control of the complement pathway, possesses a unique array of disulphide bridges. FEBS Lett. 297, 70–76. , et al. (1998). Differential regulation of the clusterin gene by Ha-ras and c-myc oncogenes and during apoptosis.

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Advances in Cancer Research by George F. Vande Woude; George Klein (Eds.)


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