Advances in Tumor Immunology and Immunotherapy by Christos E. Kyriakopoulos, Alberto J. Montero, Claudia PDF

By Christos E. Kyriakopoulos, Alberto J. Montero, Claudia Marcela Diaz-Montero (auth.), Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa (eds.)

ISBN-10: 1461488087

ISBN-13: 9781461488088

ISBN-10: 1461488095

ISBN-13: 9781461488095

Recent advances in figuring out of basic immunology have created new insights into the dynamic interactions among tumors and the immune method. This comprises new realizing of T- and B-cell interplay, immune inhibitory mechanisms together with the biology of T regulatory cells, myeloid suppressor cells, and dendritic telephone subsets.

Enhanced realizing of mechanisms underlying T-cell anergy resembling arginine deprivation, immunosuppressive cytokines, faulty innate and interferon reaction pathways, and NKG2D downregulation have all supplied new perception into suppression of anti-tumor immunity and tumor evasion.

In addition to rising knowing of tumor evasion, new immune objectives similar to CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all supply new percentages for boosting anti-tumor immunity even in tumors formerly felt to be proof against immune assault. a number of of those thoughts have already been learned within the sanatorium. the quantity will discover evolving paradigms in antigen presentation, dendritic phone biology, the innate reaction and immunosuppressive mechanisms, and rising suggestions for manipulation of the immune method for healing gain that experience learned good fortune in neuroblastoma, leukemia, cancer, lung melanoma, and allogeneic transplantation. Early successes in addition to disasters could be highlighted to supply a photograph of the kingdom of scientific immunotherapy with an eye fixed to destiny probabilities corresponding to mix treatments, adoptive T-cell move, and the retargeting of immune cells through T-cell receptor engineering.

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Additional resources for Advances in Tumor Immunology and Immunotherapy

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B regulatory cells and the tumor-promoting actions of TNF-alpha during squamous carcinogenesis. Proc Natl Acad Sci U S A. 2011;108(26):10662–7. 1100994108. 20. DiLillo DJ, Matsushita T, Tedder TF. B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. Ann N Y Acad Sci. 2010; 1183:38–57. 32 Y. Zhang et al. 21. Stockinger B, Zal T, Zal A, Gray D. B cells solicit their own help from T cells. J Exp Med. 1996;183(3):891–9. 22. Bouaziz JD, Yanaba K, Tedder TF.

When adoptive transfer of B cells into BCDM is followed by EMT-6 tumor implantation, a dramatic increase in CD4+Foxp3+ Treg was observed in B cell-reconstituted BCDM, compared to BCDM. Increased Treg number correlated with increased tumor growth in B cellreconstituted BCDM as compared to BCDM (Fig. 1). The observed increase in tumor growth was associated with decreased CD8+ T cell and NK+ cell infiltration into tumor tissue and increased infiltration of Treg and B cells into the tumor bed. CTL activity was significantly decreased in B cell-reconstituted BCDM compared to BCDM.

62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. Y. Zhang et al. of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a “vaccinal effect” of rituximab. Blood. 2009;113(16):3809–12. 1182/ blood-2008-10-185280. Kim S, Fridlender ZG, Dunn R, Kehry MR, Kapoor V, Blouin A, Kaiser LR, Albelda SM. B-cell depletion using an anti-CD20 antibody augments antitumor immune responses and immunotherapy in nonhematopoetic murine tumor models. J Immunother. 2008;31(5): 446–57.

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Advances in Tumor Immunology and Immunotherapy by Christos E. Kyriakopoulos, Alberto J. Montero, Claudia Marcela Diaz-Montero (auth.), Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa (eds.)


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