Get Fatty Acids and Inflammatory Skin Diseases PDF

By Ehrhardt Proksch (auth.), Prof. Dr. Jens-Michael Schröder (eds.)

ISBN-10: 3034887612

ISBN-13: 9783034887618

ISBN-10: 3034897626

ISBN-13: 9783034897624

Fatty acids play an incredible function within the barrier functionality of pores and skin and signify a huge resource of proinflammatory mediators corresponding to prostaglandins, leukotrienes and different lipids in inflammatory pores and skin problems. This publication combines the 2 significant services of fatty acids in dermis biology. within the first half the biosynthesis of fatty acids in pores and skin with its function in barrier functionality in addition to the function of nutritional fatty acids on pores and skin mobile functionality and within the therapy of inflammatory dermis ailments is gifted. the second one half bargains with epidermis as a resource of proinflammatory eicosanoids, in particular with the keratinocyte as an important mobile resource. Metabolism of eicosanoids in epidermis, its position in psoriasis and atopic dermatitis in addition to pharmacological inhibition of eicosanoid biosynthesis is reviewed. The e-book finishes with a bankruptcy describing the tools used for quantification of fatty acids and derivatives in dermis irritation. someone attracted to dermis body structure would receive advantages from the overviews concerning the websites of fatty acids' functionality in dermis integrity and in pores and skin inflammation.

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Biochim Biophys Acta 1081: 347-354 Fiirstenberger G, Hagedorn H" Jacobi T, Besemfelder E, Stephan M, Lehmann WD, Marks F (1991) Characterization of an 8-lipoxygenase activity induced by the phorbol ester tumor promoter 12-0-tetradecanoylphorbol-13-acetate in mouse skin in vivo. ] Bioi Chem 266: 15738-15745 Forman BM, Chen J, Evans RM (1997) Hypolipidemic drugs, polyunsaturated fatty acids and eicosanoids are ligands for peroxisome proliferator-activated receptors a and O. Proc Natl Acad Sci USA 94: 4312-4317 Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM et al (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors a and y.

J BioI Chem 256: 7730-7733 Ilchysyn A, Ilderton E, Kingsbury JA, Yardley HJ (1984) Evidence that raised levels of 29 Lars Iversen and Knud Kragballe phospholipase A2 in uninvolved epidermis of psoriasis are caused by hyperphosphorylation of an inhibitor. Br J Dermatollll: 721 34 Hong LS, Levine L (1976) Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids. Proc Natl Acad Sci USA 73: 1730-1734 35 Hirata F, Schiffermann E, Venkatasubramanian K, Salomon D, Axelrod] (1980) A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

Invest Dermatol 82:477-479 Brain SD, Camp RDR, Kobza Black A, Dowd PM, Greaves MW, Ford-Hutchinson AW, Charleson S (1985) Leukotriene C4 and D4 in psoriatic skin lesions. Prostaglandins 29: 611-619 Sampson AP, Thomas RU, Costello jF (1992) Enhanced leukotriene synthesis in leukocytes of atopic dermatis and asthma subjects. BrJ Clin Pharmacol 33: 423-430 Grabbe j, Rosenbach T, Czarnetzki BM (1985) Production of LTB4-like chemotactic arachidonate metabolites from human keratinocytes. ] Invest Dermatol 85: 527-530 Rosenbach T, Grabbe j, Moller A, Schwanitz Hj, Czarnetski BM (1985) Generation of leukotrienes from normal epidermis and their demonstration in cutaneous disease.

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Fatty Acids and Inflammatory Skin Diseases by Ehrhardt Proksch (auth.), Prof. Dr. Jens-Michael Schröder (eds.)

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